The England duo will not make the long trip to Russia to face Rostov, but Henrikh Mkhitaryan has been included in the selection by Jose Mourinho.
Wayne Rooney and Luke Shaw have been left out of Manchester United’s squad for the Europa League trip to Rostov, it has been confirmed.
Rooney has fallen out of favour with manager Jose Mourinho in recent weeks and was not included in either squad for the encounters with Saint-Etienne in the previous round of the competition.
The England captain was heavily linked with a move to China throughout January but ultimately released a statement confirming that he would stay at the club.
Shaw has also been left out of the squad despite returning to Premier League action against AFC Bournemouth on Sunday, along with the still-exiled Bastian Schweinsteiger.
Henrikh Mkhitaryan, meanwhile, has returned to the fold after missing the EFL Cup final win over Southampton and the encounter with Bournemouth due to a hamstring injury sustained against Etienne.
Eric Bailly is suspended for the first leg of the encounter but Zlatan Ibrahimovic could play despite facing disciplinary action in England for an alleged elbow on Cherries defender Tyrone Mings.